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Drug Trial Makes History As Cancer Disappears In Every Patient

More than a dozen rectal cancer patients in the United States have seen their cancer disappear after receiving experimental immunotherapy, a remarkable accomplishment, according to physicians.

Dostarlimab, a medicine that employs laboratory-produced molecules to replace antibodies in the body, was found to be effective in treating the condition in a recent drug trial.

It's hoped the drug could save lives. Credit: Alamy

Patients were given Dostarlimab every three weeks for six months during the research.

The subjects were then subjected to a series of follow-up testing, including physical exams, MRI scans, and PET scans.

However, after a year, every single one of the 18 patients who took part in the study had gone into remission.

A lot of happy tears': Cancer 'disappears' in every patient in a small drug  trial - Science News

Not only that but during the experiment, none of the patients reported any major problems.

About one out of every five patients have a negative reaction to medications like these.

The experiment, according to Luis Diaz Jr., MD, senior study author and oncologist at Memorial Sloan Kettering Cancer Center in New York City, was “ground-breaking.”

He said: “I believe this is the first time this has happened in the history of cancer.”

Andrea Cercek, MD is the lead study author and an oncologist at Memorial Sloan Kettering Cancer Center.

She said: “There were a lot of happy tears.”

Dr. Hanna K. Sanoff of the University of North Carolina’s Lineberger Comprehensive Cancer Center labeled the study as ‘small but compelling’.

Drug Trial Makes History As Cancer Disappears In Every Patient | Flipboard

She said: “Very little is known about the duration of time needed to find out whether a clinical complete response to Dostarlimab equates to cure.”

This comes after doctors revealed a new experimental therapy for patients with pancreatic cancer.

Kathy Wilkes of Ormond Beach, Florida, was diagnosed with advanced pancreatic cancer in 2018.

The 71-year-metastatic old’s cancer was reduced by 50% in just one month this year thanks to a ‘one-and-done’ treatment.

Wilkes’ disease had been spreading before he received the new experimental medicine.

Cancer disappears in patients 'first time in history' after drug trial;  Deets inside | Cancer News – India TV

Despite eight rounds of chemotherapy and an operation to remove part of her pancreas, cancer advanced to her lungs in barely a year.

Wilkes told NBC News: “When I talked to my hometown oncologist and asked him what to do, he only had one answer, and that was chemotherapy. And I said, ‘That’s not my answer’.

“I thought, ‘That is the trial I want. I knew that that was the trial that was going to save me, save my life. I just had that feeling.”

Wilkes subsequently reached out to Dr. Eric Tran, who is the author of a report on an experimental type of gene therapy that targets KRAS G12D – a type of cancer mutation.

The treatment continued for 18 days after the infusion. Credit: NEJM Group/ YouTube

She agreed to try Neoantigen T-Cell Receptor Gene Therapy, a novel experimental treatment.

Wilkes’ metastatic cancer was revealed to have shrunk by half in just one month.

The report stated: “Regression of the patient’s metastatic lung lesions was observed on computed tomography at the first clinical follow-up 1 month after the cell infusion, with an overall objective partial response according to the Response Evaluation Criteria in Solid Tumors (RECIST), version 1.1, of 62%.”

Six months after the treatment, her tumors had reduced by 72 percent.


Johnny Depp’s Lawyer Camille Vasquez Gets Promotion Following Her Trial Performance

Last week’s triumph over Amber Heard in Johnny Depp’s multi-million dollar trial was a win for more than just the former Pirates of the Caribbean star. Attorney Camille Vasquez, who made headlines for her savage cross-examinations and closing arguments during the six-week trial in Virginia, has been promoted.

Vasquez, who has been a co-lead lawyer for Depp alongside Ben Chew for less than four years, has been promoted to partner at Brown Rudnick.

Johnny Depp’s lawyer Camille Vasquez has been given a major promotion by her firm. Alamy

William Baldiga, chairman and CEO of Brown Rudnick, wrote: “We are delighted to welcome Camille to the partnership.

“Historically, we have reserved this announcement for the end of our fiscal year. But Camille’s performance during the Johnny Depp trial proved to the world that she was ready to take this next step now.”

Baldiga added: “We are incredibly proud of her and look forward to what she will accomplish as our newest partner.”

Vasquez belongs to the law firm Brown Rudnick. Credit: Alamy

Vasquez said she was ‘delighted’ by the promotion and praised her ‘uniquely talented team’. 

She wrote: “I am delighted that Brown Rudnick has given me its full vote of confidence by having me join the partnership. 

“I’m proud of the uniquely talented team I’ve had the privilege to lead, which exemplified teamwork and collaboration, and I look forward to continuing to represent Brown Rudnick’s culture of excellence.”

Vasquez, 34, is a litigation and arbitration specialist who was one of nine lawyers involved in the Heard-Depp case.

Who is Camille Vasquez? Johnny Depp's lawyer in Amber Heard trial - AS USA

Her courtroom performance won the public’s heart, and she was a critical contributor to Depp’s victory.

Vasquez allegedly mumbled “we won” with tears in her eyes after the jury’s verdict was read and Depp was given $10 million in compensatory damages.

Vasquez had mostly focused on matters alleging breach of contract or discrimination by her clients against employers before Depp’s lawsuit.

Jonny Depp's lawyer Camille Vasquez gets promoted as a partner at her law  firm | Marca

It was reported earlier this week that law firms were fighting against one another to get Vasquez on board in the wake of her sudden celebrity.

Speaking to the New York Post on 5 June, celebrity lawyer Judd Burstein correctly predicted Vasquez’s promotion to partner, saying: “No firm would allow her to have a role in a big trial like this if she wasn’t on the partner track.”

Burstein added: “There are two factors that go into making a partner – your quality of lawyering and ability to attract business. She can probably go anywhere and make a nice deal for herself.”


Jurors Were ‘Dozing Off’ During Johnny Depp Vs Amber Heard Defamation Trial

While the rest of the world was rapt, the people in the courtroom were trying to remain awake while Johnny Depp and Amber Heard battled it out on live streams.

The court stenographer for the Depp v. Heard defamation trial, Judy Bellinger, has made some shocking revelations about the contentious six-week trial.

Johnny Depp, left, and Amber Heard in the courtroom for closing arguments at the Fairfax County Circuit Courthouse in Fairfax, Va., on Friday, May 27, 2022.

“There were a few jurors who were dozing off,” Bellinger told the Law & Crime network on Monday, admitting “it was tough” to sit through the many hours of testimony.

Speaking to Law and Crime Network, Bellinger said: “I remember the jury […] were listening very intently, and unfortunately when the jury was chosen, we knew that there gonna be some that would not see it all the way through – that there were alternates. We knew who the alternates were from the start because they just picked the names randomly.” 

Bellinger said there was one alternate that stuck out as the ‘best juror’, but that even she struggled to get through the trial. 

“I watched her facial expressions, she was very deeply into every word that was being said,” she said. 

“I thought she would have made a great juror, and she did not make it to the end.” 

Going into further detail, Bellinger said: “She was playing close attention. You know, there were a few jurors who were dozing off. She never dozed off.” 

Actor Amber Heard speaks to her legal team in the courtroom at the Fairfax County Circuit Courthouse in Fairfax, Va., Friday, May 27, 2022.

When asked if the jurors who were falling asleep were in the front or back row, Bellinger replied: “Both. And it was tough because there was a lot of video deposition, and they would just sit there, and all of a sudden I’d see their head drop.” 

Multiple witnesses testified during the highly publicized and televised trial, including Depp’s ex-partner and British supermodel Kate Moss, who testified about his alleged aggression.

Psychologists testified on Heard’s mental health, as did Depp’s bodyguard, who testified about the actor’s drug use.

Depp and Heard testified themselves, with Heard saying of their divorce in 2016: “I knew if I didn’t I’d likely not literally survive. I was so scared that it was going to end really badly for me and I really didn’t want to leave him, I loved him so much.

Actor Johnny Depp arrives in the courtroom at the Fairfax County Circuit Court in Fairfax, Va., Wednesday May 4, 2022.

“I would have done anything but I couldn’t do that one thing, I couldn’t stay.”

Depp claimed in a statement after winning the lawsuit that he had been the victim of “false, very serious, and criminal allegations,” which had generated an “endless barrage of hateful content” and had a “seismic impact” on his life and business.

Amber Heard awaiting the verdict. Credit: Alamy

He added: “The jury gave me my life back. I am truly humbled.”

In her own statement issued after the verdict, Heard said: “I’m sad I lost this case. But I am sadder still that I seem to have lost a right I thought I had as an American – to speak freely and openly.”


The lion goes Viral as the Chinese Zookeepers Deny Giving Lion Straight Bangs

The internet has gone crazy over a lion in China’s Guangzhou Zoo, notably over its fringe haircut. After some quite amusing photographs of the hairstyle went viral online, Chinese zookeepers denied giving a male lion a’ straight bang.’

Of course, lions, dubbed “King of the Jungle,” attribute much of their animal world success to their lofty chests, swift speeds, and sleek-looking manes.

Lion in China zoo turns heads for sporting bangs, goes viral as keepers deny  giving it a haircut | Malay Mail

However, in a recent shot taken at the Guangzhou Zoo in China, one lion appeared to be less than regal, sporting some strange bangs that zookeepers have denied having anything to do with.

Instead of a large and wild mane, one white lion was seen with a bowl cut – complete with an oddly straight fringe.

On the Chinese microblogging platform Weibo, a user posted images of the lion in question, Hang Hang, with surprising straight bangs.

Many people disputed if the Guangzhou Zoo’s caretakers had anything to do with Hang Hang’s unusual-looking mane after seeing the post.

The zookeepers suggested that it was the high humidity that caused the lion's mane to hang downwards. Credit: Guangzhou Zoo/Weibo

In response to the claims, zookeepers have argued that the mane’s lack of luster is due to excessive humidity levels rather than a shoddy trim.

Staff from the Guangzhou Zoo’s official Weibo account re-shared the original post that triggered the whole issue.

Keepers claim that hot temperatures are to blame for the ‘bangs,’ which cause the once bouncy mane to droop downwards. They also stated that they would not mess with the white lion’s natural locks, blaming the floppy hairstyle on the thick and muggy air.

Lion in China zoo goes viral for fringe, zookeepers deny giving it haircut  - Mothership.SG - News from Singapore, Asia and around the world

Hang Hang and his strange mane have swiftly become a zoo attraction in and of themselves. The post and subsequent re-sharing via the Guangzhou Zoo account became viral on the Weibo site, garnering a lot of media attention.

The white lions, Hang Hang’s species, are a highly uncommon subspecies of lions. White lions are not albino, despite their paler color than their counterparts.

The white fur is thought to have developed from a less-severe mutation in the same gene that causes albinism and is caused by a recessive trait known as leucism.

Hang Hang is part of a rare lion subspecies. Credit: Guangzhou Zoo/Weibo

Hang Hang and his subspecies, which range in color from blonde to white, were declared technically extinct in the wild between 1992 and 2004 by the Global White Lion Protection Trust.

There is, however, a positive aspect for Hang Hang and the rest of his endangered species.

The lions were returned to their original habitat by the Global White Lion Protection Trust in 2004.


The Psychiatrist who testified against Johnny Depp, says he has sustained an ’emotional concussion’

Dr. David Spiegel, the eccentric psychiatrist brought in by Amber Heard to testify that Johnny Depp exhibited “narcissistic” characteristics, has now claimed that the criticism he experienced caused him to suffer an “emotional concussion.”

On the 23rd of May, Heard’s legal team called Dr. David Spiegel, a psychiatrist, and physician, to testify in her defense.

Why is there no trial between Johnny Depp and Amber Heard today and when  will it resume? | Marca

Elaine Bredehoft, Heard’s lawyer, asked Spiegel to comment on the psychological profile of persons who have experienced and perpetrated IPV, and whether or whether it was compatible with Depp’s behavior.

He said: “In my opinion – based on my review of the evidence, based on my clinical experience, based on my publishing experience, based on my teaching experience – that Mr. Depp has behaviors that are consistent with both someone who has a substance use disorder as well as behaviors of someone who is a perpetrator of intimate partner violence.” 

Psychiatrist who testified in Depp v. Heard trial says he's suffered 'emotional  concussion' from backlash - VT

Since testifying, the psychiatrist has now revealed the negative backlash he has received from Johnny Depp fans via an op-ed for Newsweek titled: “I Testified in the Heard vs. Depp Trial. The Backlash Has Been Horrific.”

He wrote: “I drove to my hotel and around an hour later, at about 4 pm, my wife called me and said, ‘Listen, I don’t want you to look at what’s being said.

“I asked her how horrific it was, and she told me it was pretty bad.

Johnny Depp fans unleash hundreds of negative reviews on psychiatrist after  he testified for Amber Heard -

“I’m not a social media expert, far from it, so I didn’t expect the whole horrific post-trial backflow.

“It’s been a little stunning for me.

“The volume of it, from the personal attacks on who I am and what I present like, to what I look like and say, was obviously a little hurtful.

“I deal with people for a living, so I tried to understand where people were coming from.

Spiegel added: “I’m an adult, it’s not the first time I’ve been criticized, but never like that. On that Monday and Tuesday, I had what I’d describe as an emotional concussion.

Johnny Depp fans spam psychiatrist who testified for Amber Heard: 'This  idiot' - CELEBRITY GIG MAGAZINE

“It wasn’t physical, I didn’t get hit on the head, it was emotional because the feedback afterward left me a little on the numb and dazed side. I slept a lot on Monday and Tuesday.”

He went on to say: “I would have liked Mr. Depp to get ahead of this and to have said, ‘Listen, I understand you are upset, but there are ways to express how to be upset’.

Johnny Depp testified a quote where he said he'll hit people when angry and  doesn't 'care what the repercussions are' may have been a reference to  paparazzi

“The fact that he hasn’t probably says potential volumes about him. Ms. Heard hasn’t come out and said anything either, but my opinion is that she is the most vulnerable person in this situation.”


Johnny Depp Hired Lawyer After Watching Her On Netflix Series

Johnny Depp reportedly hired one of the lawyers from his recent defamation trial against his former wife Amber Heard after seeing her on a hit Netflix show.

Following an op-ed she penned in the Washington Post in 2018, Mr. Depp sued his former lover Amber Heard for defamation, which was judged to be defamatory by a US jury on Wednesday.

Credit: Alamy

Depp chose Kathleen Zellner, an American lawyer who appeared in the Netflix film Making a Murderer because he saw her on the show and remembered her saying she was “the last person someone would employ if they were guilty.”

For those unaware, the show ‘tells the real story of the case of Steven Avery, who was charged and then convicted for the murder of photographer Teresa Halbach, alongside his nephew Brendan Dassey, just a few years after being released from prison for a wrongful sexual assault conviction’, as per Radio Times.

Kathleen Zellner is 'so happy' for Johnny Depp. Credit: Law and Crime Network

Following the verdict, Zellner said: “He called me and left a voicemail at my office.

“I didn’t really believe that it was Johnny Depp at all, but it sounded like him and he left the phone number and just said he wanted to talk to me.”

She added: “It was indicative to me of the fact that he was innocent, because he said, ‘I saw on Making a Murderer, where you said that you’d be the last person someone would hire if they were guilty because you would find out about it’.

“And I was very struck with that that that’s what motivated him to contact me.”

She also said speaking about the case specifically: “I think that the jury absolutely reached the right verdict.

“I think it’s hugely vindicating and exonerating for Johnny; it’s something he’s really had to deal with, particularly since the UK verdict.

“I think it’s a great victory.

Johnny Depp's heartwarming hug with lawyer goes viral as case closes: See

“It reassures me how well juries work and why we can trust jurors to come to the right decision.

“I think the case boiled down to a contest of credibility.” 

She added: “I’m so happy for him. He’s been reborn.”

Zellner believes the reason why Heard lost the case was due to the ‘forensic evidence’.

“It failed on the forensic evidence, those beating and abuse she described did not happen,” she added.

“I’ve been doing criminal cases for over thirty years and the forensic evidence simply wasn’t there. She just did not suffer those injuries.”